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Application Value of Ginsenoside Rg3 in Targeting BCSCs to Treat Breast Cancer
Application Value of Ginsenoside Rg3 in Targeting BCSCs to Treat Breast Cancer

Introduction Ginsenoside Rg3 is Panaxanediol type tetracyclic triterpenoid saponin monomer extracted from the root of Panax ginseng, which has a wide range of pharmacological effects including anti-tumor, neuroprotect

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Fathoming Out the Role of NMN in Maintaining the Colon Health of Ageing Mice
Fathoming Out the Role of NMN in Maintaining the Colon Health of Ageing Mice

Introduction The gut is a diverse and dynamic microbiotic system. There are about 100 trillion microorganisms in the gut, which is mainly composed of anaerobic, partially anaerobic, and aerobic bacteria. In the pr

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Targeting NAD+ Salvage Pathway as a Potential Approach to Combat Obesity
Targeting NAD+ Salvage Pathway as a Potential Approach to Combat Obesity

Introduction Mar 4th is determined as the World Obesity Day. World Obesity Federation, UNICEF and WHO have hosted a global youth-led webinar to talk about obesity & youth. The obesity crisis has gradually attr

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Tailoring Personalized Dosage Regimens of NMN Based on NAD Concentration
Tailoring Personalized Dosage Regimens of NMN Based on NAD Concentration

Introduction Nicotinamide mononucleotide (NMN), one precursor of nicotinamide adenine dinucleotide (NAD+), has been ascertained to be implicated with multiple biological processes such as cellular redox regulation and

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NR as a Promising Therapeutic Candidate for Alpers' Disease
NR as a Promising Therapeutic Candidate for Alpers' Disease

Introduction Alpers' disease is both a neurodegenerative disorder and a metabolic disorder, which is tightly linked to mitochondrial dysfunction and mutations in the catalytic subunit of polymerase

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Deep Insight on NADH: a Potential Medical Arsenal
Deep Insight on NADH: a Potential Medical Arsenal

  Introduction NADH (reduced form of NAD+) serves as a carrier of biological hydrogen and an electron donor, which participates in diverse physiological processes such as protein synthesis, DNA repair,

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Frontier Dynamics on the Molecular Mechanism of Ginsenoside Rh2 Against Tumor
Frontier Dynamics on the Molecular Mechanism of Ginsenoside Rh2 Against Tumor

  Introduction Ginsenoside Rh2, one protopanaxadiol (PPD)-type rare ginsenoside in Panax ginseng, is uncovered to possibly have broad-spectrum pharmacological activity in diversified tumors. It is utili

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SLC25A51 Functions as an NAD+/NADH Redox Decoupler in AML
SLC25A51 Functions as an NAD+/NADH Redox Decoupler in AML

Introduction Solute carrier family 25 member 51 (SLC25A51) is perceived as a mammalian transporter, which is capable of importing oxidized nicotinamide adenine dinucleotide (NAD+) into mitochondrial matrix. Remark

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The Molecular Mechanisms Underlying the Interaction Between NAD+/NMN and DBC1
The Molecular Mechanisms Underlying the Interaction Between NAD+/NMN and DBC1

Introduction Oxidized form of nicotinamide adenine dinucleotide (NAD+) and its precursor nicotinamide mononucleotide (NMN) have been uncovered to restore DNA repair and prevent cancer progression via the deleted i

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